ARTICLE ARCHIVE
Article archive
Original dates and URLs are retained. Use the refreshed guides for the revised explanations.
How to use this archive
These articles reflect the site’s earlier development. The review found material corrections in some numerical and interpretative examples. Links to revised explanations are provided below. Original publication dates and addresses are retained where articles have been updated.
Statistics & interpretation
Revisit the calculations and distinguish analytical from clinical questions.
Quality & uncertainty
Use the updated material-selection and evidence guides.
2024
- Measurement Uncertainty and Third-Party Controls — Independence does not guarantee absence of bias. Revised guide →
- Impact of Traceability and Stability of IQC on Measurement Uncertainty Estimation in Clinical Laboratories — Separate control targets from the calibration traceability chain. Revised guide →
- IQC and MU: Matrix Effect, Variability, and Third-Party Materials — Material behaviour needs evidence; avoid casual assay modifications. Revised guide →
- Measurement Uncertainty and Control Material Selection — Control origin and assigned-value status are overlapping characteristics. Revised guide →
- Understanding the Root Mean Square (RMS) and Root Sum of Squares (RSS): A Practical Guide for Medical Laboratory Scientists — The old RMSE calculation is incorrect; use the revised worked example. Revised guide →
- Understanding Standard Deviation and Its Role in Measurement Uncertainty Analysis — Correct SD/SE and sample-variance treatment. Revised guide →
- Measurand Characteristics and Measurement Uncertainty Assessment — Clarify quantity definitions and avoid accuracy guarantees. Revised guide →
2021
- Absolute vs. Relative Uncertainty: Impact on Medical Laboratory Results — Constant relative uncertainty requires supporting evidence. Revised guide →
2020
- pathologyuncertainty.com goes international — Historical teaching visit.
2018
- The Most Useful Data Sources for Uncertainty Analysis in Laboratory Pathology – Part Two — Do not assume all existing data can be converted into independent MU terms. Revised guide →
2017
- The Most Useful Data Sources for Uncertainty Analysis in Laboratory Pathology – Part One — Map effects to evidence and prevent overlap. Revised guide →
- The Top 10 sources of uncertainty in Pathology assays — Separate contributors, evidence sources and calculation methods. Revised guide →
- Calibration Uncertainty? – Part One: What is it? — Correct traceability and stability wording; avoid assuming normal calibration outputs. Revised guide →
- Factor VIII assays – Part One: The Measurand — Specialist historical example; requires a separate haemostasis review.
- Budgeting the aPTT – Part Two: Modelling the aPTT — Specialist historical example; bias and overlap treatment need review.
- Centralised pathology: Is tailored uncertainty necessary? — Do not require a pooled estimate for every known-analyser result. Revised guide →
- Putting MU in context for pathology: What can we use it for? – Part two: Clinically significant difference — The old reference-interval and clinical-significance interpretation needs correction. Revised guide →
- Budgeting the aPTT – Part One: Definition of the measurand: — Specialist historical example; terminology and procedural claims need review.
- Putting MU in context for pathology: What can we use it for? – Part one: Analytical difference — Define the analytical comparison and its coverage assumptions. Revised guide →
For the complete learning pathways, return to Topics.